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Glossary ROS reactive oxygen species DFO deferoxamine PUFA, polyunsaturated fatty acid PL phospholipid RPL8 ribosomal protein L8 IREB2 iron response element binding protein 2 ATP5G3 ATP synthase F0 complex subunit C3 CS citrate synthase TTC35 tetratricopeptide repeat domain 35 ACSF2 acyl-CoA synthetase family member 2 HSPB1 heat shock protein -1 PTGS2 prostaglandin-endoperoxide synthase 2 CNS central nervous system LOOH lipid hydroperoxide GSH glutathione CoQ 10 coenzyme Q 10 4-HNE 4-hydroxy-2-nonenal MDA malondialdehyde SFA saturated fatty acid MUFA monounsaturated fatty acid AA arachidonic acid AdA adrenic acid PE phosphatidylethanolamine ACSL4 acyl-CoA synthetase long-chain family member 4 LPCAT3 lysophosphatidylcholine acyltransferase 3 TZD thiazolidinedione TRO troglitazone PIO pioglitazone ROSI rosiglitazone LOX lipoxygenase L pentadienyl radical OH hydroxyl radicals LO alkoxy groups HO 2 hydroperoxyl radicals LOO peroxy radical H 2 O 2 hydrogen peroxide RTA radical trapping antioxidant Fer-1 ferrostatin-1 Lip-1 liproxstatin-1 Tf transferrin TfR transferrin receptor DMT1 divalent metal transporter 1 LIP labile iron pool FT ferritin FTH1 ferritin heavy chain 1 FTL ferritin light chain NCOA4 nuclear receptor coactivator 4 FPN ferroportin GPX4 glutathione peroxidase 4 Se selenium L-OH lipid alcohol RSL3 Ras-selective lethal 3 Sec selenocysteine Glu glutamate Cys cysteine Gly glycine BSO buthionine sulfoximine GCL glutamate-cysteine ligase IPP isopentenyl pyrophosphate SQS squalene synthase HMG-CoA 3-hydroxy-3-methyl glutaryl-coenzyme A HMGCR HMG-CoA reductase FSP1 ferroptosis suppressor protein 1 NRF2 nuclear factor erythroid 2-related factor 2 TXNRD1 thioredoxin reductase 1 NADK NAD + kinase NOX NADPH oxidase DPI diphenylene iodonium TCA cycle tricarboxylic acid cycle Keap1 Kelch-like ECH-associated protein NQO1 NAD(P)H quinone oxidoreductase-1 HO1 heme oxygenase-1 ARF auxin response factor FOCAD focadhesin FAK focal adhesion kinase OHSC organotypic hippocampal slice culture PD Parkinsons disease AD Alzheimers disease HD Huntingtons disease ICH intracerebral hemorrhage MCAO middle cerebral artery occlusion Hb hemoglobin SNpc substantia nigra pars compacta FAC ferric ammonium citrate MPTP 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine A amyloid- NFT neurofibrillary tangle HP hippocampi FC frontal cortices CDDO 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid ARE antioxidant response element References 1 AgmonE.SolonJ.BassereauP.StockwellB

J Chem Theory Comput 14:60636075