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Macromolecule Content Total Structure Weight: 525.75 kDa Atom Count: 34,893 Modeled Residue Count: 4,474 Deposited Residue Count: 4,824 Unique protein chains: 1 Experimental Data Method: X-RAY DIFFRACTION Resolution: 2.70 R-Value Free: 0.226 (Depositor), 0.227 (DCC) R-Value Work: 0.207 (Depositor), 0.208 (DCC) R-Value Observed: 0.208 (Depositor) Unit Cell : Software Package: Revision History (Full details and data files) Version 1.0: 2020-05-27 Type: Initial release Version 2.0: 2020-07-29 Type: Remediation Reason: Carbohydrate remediation Changes: Advisory, Atomic model, Data collection, Derived calculations, Structure summary Version 3.0: 2020-12-09 Type: Coordinate replacement Reason: Atomic clashes Changes: Advisory, Atomic model, Data collection, Database references, Derived calculations, Non-polymer description, Refinement description, Structure summary Version 3.1: 2020-12-16 Changes: Database references Version 3.2: 2024-05-15 Changes: Data collection, Database references, Refinement description

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There is less information on effectively targeting NF-B signaling to reduce transplant rejection, as current alternatives to broad immunosuppressive treatments often affect multiple immune cells