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Avoid Toxins: Limiting exposure to alcohol, tobacco, and environmental pollutants reduces the demand on glutathione, allowing it to focus on essential cellular functions

Copper overload impairs mitochondrial electron transport, leading to excessive ROS production and a diminished antioxidant capacity

While the results of that trial suggested that vitamin E alone did not produce any significant clinical benefits [90] or influence CSF amyloid or tau species levels [91], a recent meta-analysis that included the cohort studies we examine here yielded a pooled odds ratio (OR) of 0.799 for PD development when low versus high vitamin E intake groups were compared [92]

Review of clinical trials evaluating safety and efficacy of milk thistle ( Silybum marianum [L.] Gaertn.)