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Multiple agents are involved in cardiac hypertrophy

The thyroid can become overactive or underactive, or the body can start to produce antibodies against its own thyroid or thyroid hormone receptors

Somewhat contradictory to the observations in animals, Savage et al (56) reported 27 prepubertal children with severe GH insensitivity syndrome (GHIS or Severe Primary IGF Deficiency (SPIGFD)) to have a median (range) birth weight SDS of -0.72 (1.75 - (-3.29)) and birth length SDS of -1.59 (0.63 - (-3.63))