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An overdose of Cyanocobalamin / Vitamin B12 + Folic Acid + Niacinamide + Vitamin C / Ascorbic Acid may result in side effects like diarrhoea, skin rashes, nausea, loss of appetite, skin flushing, and headaches

Some previous studies have suggested that estrogen influences folate metabolism and effects, but it is unclear whether this interaction contributes to the observed differences in MASLD patients ( Previous studies have shown that patients with NAFLD have lower serum folate and vitamin B12 concentrations compared with the general population ( Several published studies have investigated the correlation between folate/vitamin B12 concentrations and mortality in the general population, but the results have been inconsistent

Enteral vitamin B12 supplementation is effective for improving anemia in patients who underwent total gastrectomy

"Curcumin ameliorates hyperuricemia and gout-induced damage via modulating the ROS-dependent NEK7-NLRP3 inflammasome activation"