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ERAD helps mitigate this burden by degrading these proteins, thereby preventing their aggregation and the subsequent activation of detrimental pathways, such as chronic ER stress, autophagy dysfunction, and apoptotic signaling

the significance of glutathione levels in aging is considered also in relation to therapeutic possibilities and supplementation strategies Aimed at increasing glutathione and related defenses to improve health status and counteract aging processes in humans

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doi: 10.7759/CUREUS.1004 62 KlebanoffSJ