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Abbreviations CCA: Cholangiocarcinoma SLC: Solute carrier FGFR: Fibroblast growth factor receptor IDH1: Isocitrate dehydrogenase 1 -KG: Alpha-ketoglutarate ROS: Reactive oxygen species ACSL4: Acyl-CoA synthetase long chain family member 4 LPCAT3: Lysophosphatidylcholine acyltransferase 3 GPX4: Glutathione hydroperoxidase 4 OGC: Oxoglutarate carrier PUFAs: Polyunsaturated fatty acids HR: Hazard ratio TCGA: The Cancer Genome Atlas GEO: Gene expression omnibus IHC: Immunohistochemistry m: Mitochondria membrane potential TMRE: Tetramethylrhodamine ethyl ester perchlorate ETC: Electron transport chain PEBP1: Phosphatidylethanolamine binding protein 1 Fer-1: Ferrostatin-1 IPA: Ingenuity pathway analysis NRF2: Nuclear factor erythroid 2-related factor 2 CUL3: Cullin3 CRLs: Cullin-RING E3 ligase complex HIF-1: Hypoxia inducible factor 1 subunit alpha GSH: Glutathione ALOX: Arachidonate lipoxygenase ICD: Immunogenic cell death DAMPs: Damage-associated molecular patterns HMGB1: High-mobility group box 1 ATP: Adenosine 5-triphosphate CRT: Calreticulin References Elvevi A, Laffusa A, Scaravaglio M, Rossi RE, Longarini R, Stagno AM, et al