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Introduction Intrauterine inflammation (IUI) is the primary cause of spontaneous preterm birth and predisposes neonates to long-term sequelae, including adverse neurological outcomes, and accounting for approximately 35% of neonatal deaths in 2017 ( Pro-inflammatory stimulation causes changes in the maternal immune system and placental microenvironment, a process in which placental macrophages may play an important role

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DNA methylation, histone modifications and ncRNAs often act in concert at the same loci

Moazzam-Jazi M, Lanjanian H, Maleknia S, Hedayati M, Daneshpour MS