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Results: Evidence suggests that Lycii Fructus and its metabolites can improve male reproductive function and sperm quality by modulating the hypothalamicpituitarygonadal axis, alleviating oxidative stress, inhibiting testicular cell apoptosis, suppressing pro-inflammatory factors, reducing testicular fibrosis, and regulating autophagy

A key repressor of this signaling, phosphatase and tensin homolog deleted on chromosome 10 (PTEN), dephosphorylates PIP 3 to PIP 2 regulating the activity of PI3K/AKT 66

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Caspase-1 engages full-length gasdermin D through two distinct interfaces that mediate caspase recruitment and substrate cleavage