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doi: 10.1021/acschemneuro.1c00523 146 SuLDWangNHanJShenY

Arita and Costa 2009

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The results of the open-label extension showed also that longer exposure to opicapone did not increase motor complication rates and interestingly a larger percentage of patients randomised to opicapone in the double-blind phase (early starters) remained free of motor complications (score of 0 on the MDS-UPDRS part IV) compared to those starting opicapone at open-label baseline (80.2% vs 69.7%, p = 0.1)