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Oxidative stress and the pathogenesis of Alzheimer's disease

These findings and interpretations are indirectly supported by a recent report on fatigue in the long COVID-19 syndrome where lower peripheral serotonin was observed in patients than in healthy controls ( Peripheral 5-HT is produced and secreted by the enterochromaffin cells in the gastrointestinal tract where it regulates intestinal mobility

Among the proposed mechanisms for these effects, the reduction of toxic metabolites from fatty acids, especially LCAC under ischemic conditions, increased glucose oxidation during reperfusion, and consequently the reduction of lactate and H+ ion accumulation, resulting in the inhibition of acidosis in myocardial cells during ischemia, as well as the inhibition of harmful effects of free radicals released during reperfusion, are more prominently noted

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