arabidopsis c lip artt Pre-exposure of to the abiotic or biotic environmental stimuli “chilling” or “insect eggs” exhibits different transcriptomic responses to herbivory Structure of Arabidopsis roots. Drawings – RCSB PDB - 9J34: Cryo-EM

Up to 3 years of safety data from an integrated analysis Most common side effects The most common adverse events (10%)* were nasopharyngitis (16.7%), upper respiratory tract infection (14.4%), urinary tract infection (12.9%), injection site reactions (36.4%), abdominal pain (18.2%), fatigue (18.2%), headache (16.7%), and cough (12.1%)consistent with those reported in the original studies Serious side effects Two serious adverse events deemed related to EMPAVELI occurred: 1 case of biliary sepsis (severe infection of the gallbladder and associated structures) in a patient who came from the PEGASUS study and 1 case of sepsis (severe, potentially life-threatening infection throughout the body) in a patient who came from the PRINCE study During the long-term integrated analysis, 1 person taking EMPAVELI had side effects related to blood clots

PMID: 154 KuangFLiuJTangDKangR

Nucleic Acids Res 45: 39853996

Mechanism of Action Research suggests that Pinealon may influence gene expression in neural cells