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The three receptors Retatrutide targets are: GLP-1 (Glucagon-Like Peptide-1) Receptors control appetite signaling in the brain and slow gastric emptying

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In the Macromolecules study, systematically swapping the amino acids on the hydrophobic face of the peptide changed its temperature- and pH-dependent gelling behavior, demonstrating that hydrophobic content controls assembly more than sheet propensity