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This landmark report demonstrates rapid-onset antidepressant effects of ketamine dependent on the activation of the mTOR pathway and increased number and function of new spine synapses in the PFC of rats

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The neuroprotective effect of omega-3 PUFA supplementation on TBI rats has been studied, and the direct interaction between cytoplasmic Beclin-1 and Bcl-2 induced by increasing SIRT1 activity has been studied, demonstrating the link between autophagy and apoptosis (99)