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ROS induce inflammation by increasing the production of pro-inflammatory cytokines, especially IL-1, IL-8, and TNF- (176, 177)

This results is in agreement with several studies demonstrated that MTX induces oxidative stress in tissues companied with decreased antioxidants levels [38, 69]

However, tandem mass spectrometry with electrospray ionisation has been used to measure TMA and TMAO following derivatisation of trimethylamine with ethyl bromoacetate to form ethyl betaine bromide