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Description

Interestingly, the E3 ligase TRIM21 limits mtDNA release by promoting VDAC2 degradation

The optimized experimental conditions included the pH- and time-dependent stability of GSH, stability of derivatized products of GSH with optimal concentration and incubation time of DTNB, incubation time of GSH with the test chemicals, and molar ratios of GSH to the test chemicals

The mechanisms remain unknown and the possibility that GSL-degradation products - allyl-ITC in the present case - might trigger this response by being perceived as DAMPs by a receptor, such as one of those described above, either directly or indirectly constitutes an interesting aspect worthy of further investigations