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Myeloma cells exhibit a metabolic phenotype characterized by enhanced glycolytic flux for ATP production, glucose to lactate conversion and reduced mitochondrial OXPHOS (166168)

Gautham Reddy 6 Christophe Corpechot 7 Susheela Carroll 8 Ke Yang 9 Daria Crittenden 8 Charles McWherter 9 , 1 Liver Institute Northwest, 2 California Pacific Medical Center, 3 Weill Cornell Medical College, New York, NY, 4 California Liver Reasearch Institiute, 5 Beth Israel Deaconess Medical Center, Boston, MA, 6 University of Chicago Medical Center, 7 Saint-Antoine Hospital, Paris, France, 8 CymaBay Therapeutics Inc, 9 CymaBay Therapeutics Background: Alkaline phosphatase (ALP) is an important marker in primary biliary cholangitis (PBC) associated with risk for disease progression

Diets or behavioural changes (e.g., exercise) that boost the NRF2 system may be important avenues to reduce the risk of neurodegenerative disease

By employing transfer learning across sessions, we could significantly reduce the number of calibration trials from 50 to 20 without compromising detection accuracy, which was 80.8% on average