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Figure 2 2.1 Iron homeostasis Iron is crucial for preventing lipid peroxidation in the process of ferroptosis ( The skin serves multiple functions, acting as a protective barrier against external physical, chemical, and biological factors, while also playing roles in temperature regulation, sensory transmission, and immune responses ( However, an imbalance of iron ions, whether in excess or deficiency, can have adverse effects on the skin microenvironment

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Nat Commun 11(1):1320 Kreitz J, Schnfeld C, Seibert M et al (2019) Metabolic plasticity of acute myeloid leukemia