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Front Microbiol 11 , 1990 (2020)

A 1997 study in Journal of Physiology (Paris) reported effects of the pentadecapeptide in non-steroidal anti-inflammatory-agent gastrointestinal-lesion and adjuvant-arthritis models in rats, an early signal that the group intended to characterize the compound well beyond the gastrointestinal tract [3]

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Beyond cSCC, elevated DHODH expression has been associated with enhanced proliferation, metastatic potential, and poor prognosis in diverse malignancies, including lung, breast, colorectal cancers, and neuroblastoma [11, 21, 23,24,25], underscoring the broad therapeutic relevance of DHODH across cancer types