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Research has explored whether NNMT inhibitions effects extend beyond direct enzyme activity to broader metabolic reprogramming, including observations of altered mitochondrial function, lipid oxidation, and gene expression in research models

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It is noteworthy that the volunteers included in this study had mild COVID-19 in 2021, prior to the emergence of the SARS-CoV-2 Omicron variant and when the Brazilian population had not completed the full COVID-19 vaccination schedule