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Oncol Ther 9 , 385450 (2021)

doi: 10.1038/ncb2521 100 CuiHLiuYJiangJLiuYYangZWuSet al

The Bottom Line Glutathione is an antioxidant thats critical to energy production

While several mTOR inhibitors do not show clinical benefits, AZD2014 is proposed as a promising drug for radiosensitizing glioblastoma stem cells (GSCs) in vitro and in vivo, and is currently being evaluated in clinical trials (Phase I NCT02619864)