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This dual mechanism is what makes tirzepatide more effective than single-agonist medications

Nat Cell Biol 13:453460

Kato M, Lin S (2014) Regulation of NAD + metabolism, signaling and compartmentalization in the yeast Saccharomyces cerevisiae

With the caveat that candidate gene approaches have been fast to identify risk genes for psychiatric disorders, but strikingly slow to replicate these findings when they occur, it is nonetheless of some relevance to review the most consistent findings from this approach