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(2020) 69:S22536

Among the most widely used mechanisms are reduction-sensitive disulfide (-SS-) and diselenide (-SeSe-) linkages, which can be cleaved by intracellular GSH to activate drug release or imaging functions [16]

Venlafaxine ER blocks the norepinephrine transporter in the brain of patients with major depressive disorder: a PET study using [18F]FMeNER-D2

Overall these alterations in metabolism pathways resulted in a substantial reduction in the levels of metabolites such as aspartate, asparagine, glutamine, histidine, N-formimino-glutamate, sarcosine, and ethanolamine phosphate in LC patients ( Figure 4B , Supplementary Figure 3B )