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[DOI] [PMC free article] [PubMed] [Google Scholar] 214.Pitarresi G, Fiorica C, Palumbo FS, Rigogliuso S, Ghersi G, Giammona G

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The Logistics (BPC-157): Ensures vascular supply

What Makes Periorbital Skin So Vulnerable A 2019 clinical assessment published in Clinical, Cosmetic and Investigational Dermatology confirmed that under-eye dark circles correlate with measurably thinner skin, higher hemoglobin index (a marker of vascular prominence), and a higher melanin index all pointing to both vascular and pigmentary contributors rather than just one single cause