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177,178,179 The new small molecule inhibitors are gradually being discovered, such as, gallated catechins (EGCG, GCG, ECG, CG), as the competitive inhibitors of NADP + , repress the activity of G6PD and suppress NADPH production

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In the latter reaction, the methyl group of levomefolic acid is transferred to homocysteine to produce tetrahydrofolate and methionine

When the integrity of the intestinal barrier is compromised, it results in increased intestinal permeability and subsequent release of gut-derived endotoxin (Nie et al., 2023)