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Both processes are highly sensitive to androgen action, but there are data also strongly suggesting that AGD is influenced by additional mechanisms/modalities outside the linear, and canonical, testosterone-DHT-AR signaling pathway in a way that nipple regression is not

Gut permeability, inflammation, and metabolic disease

Treated animals showed improved load-to-failure, reduced inflammatory infiltrates, and enhanced tendon-to-bone healing

That distinction matters clinically because it preserves the feedback loop that governs GH secretion, reducing the risk of the side effects associated with exogenous HGH administration at therapeutic doses