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Renal cancer cells with FH loss are resistant to cystine deprivation-induced ferroptosis [81]

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Covers nausea rates from pooled STEP and SURMOUNT data, why patients discontinue, the lean mass question, gallbladder and pancreatitis risk, the thyroid boxed warning, and what happens after stopping

This is structural evidence that movement of Y296 is associated with binding of NADPH and suggests that this residue may be acting to block the active site FAD from non-specific reduction and/or reoxidation and thus confines the redox activity of reduced SmTGR