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Among the various natural products, ubiquitous hydroxylated flavonoids have been documented as a potent inhibitor of tyrosinase due to their structural similarities with tyrosinase substrates, such as l-tyrosine and l-DOPA, and substantial antioxidant properties 11,29,30,31

As mentioned above, it is well documented across species that prolonged sleep deprivation increases susceptibility to oxidative stress in the form of increased mitochondrial ROS which in turn increases sleep pressure

Although the mechanisms remain uncertain, it is hypothesized that the term HPA axis is more susceptible to glucocorticoid-mediated downregulation of central GR expression, leading to impaired negative feedback regulation