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Large cross-sectional [48] and longitudinal [9] epidemiological studies suggest that smokers are about 1.52 times as likely as nonsmokers to report ED, even after controlling for confounding cardiovascular risk factors

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For example, they were measured in human lung tissue, exfoliated bladder cells, oral mucosa, exfoliated oral cells, and cervical cellsall sites of tobacco-derived cancersand in surrogate tissues (e.g., carcinogenperipheral blood lymphocyte DNA adducts) (Mancini et al

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