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We and others have reported that ceramides affect mitochondria function favoring changes in membrane chemical composition, inhibition of the respiratory chain, overproduction of ROS reducing intracellular ATP production and causing oxidative stress and mitophagy in brain (Camacho-Morales et al., 2024)

Commonly used in studies of telomere biology, oxidative-stress defense, cell-cycle checkpoints, and immune-senescence in fibroblast, epithelial, and lymphocyte assays