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10.1007/s00404-016-4148-0 Summary Keywords metformin, polycystic ovary syndrome, endometriosis, premature ovarian failure, gynecologic malignancies, ovary, uterus Citation Nie P, Wang M, Mo Y, Zhou H, Zha Q, Lash GE and Li P (2025) Metformin in gynecological disorders: pathogenic insights and therapeutic implications

Oral administration of cysteamine, although efficacious for cystine depletion in nephropathic cystinosis, is associated with poor patient compliance due to the unpalatable taste, odor of sulfur, and gastrointestinal side-effects such as nausea, vomiting and pain, coupled with a requirement for frequent, high dosing to overcome extensive first pass metabolism of the cysteamine

Future validation must therefore prioritize standardized quantification protocols to rigorously assess the true comparative advantage of chemical strategies