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Its inhibition reduces in vitro ferroptosis in mesangial cells induced by a medium high in glucose, as evidenced by a decrease in ACSL4 and an increase in GPX4 (66)

Epidemiological studies have consistently identified hyperuricemia as a key contributor to hypertension (11-14)

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Figure 2: Examples of Iron-Sulfur Clusters Image credit: Marvin, Chemaxon 3 The way the cluster is connected to the larger protein adds variation and fine-tuning