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Heart (British Cardiac Society) , 106 (9), 691697

David Spence The novel finding that grapefruit juice can markedly augment oral drug bioavailability was based on an unexpected observation from an interaction study between the dihydropyridine calcium channel antagonist, felodipine, and ethanol in which grapefruit juice was used to mask the taste of the ethanol

Classic pharmacokinetic work found that after intramuscular injection, hydroxocobalamin produces a more sustained rise in serum cobalamin and less urinary loss than an equivalent dose of cyanocobalamin, because it binds plasma proteins more avidly and is retained longer