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1 and 2), upregulated several regulatory proteins that play a key role in tumor suppression, DNA repair, humoral defense, insulin signaling, and downregulated several tumor promotor proteins

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Samples were quantified using densitometry by quantifying the volume of the primary SUMOylated TDP-43 band at ~ 98 kDa, standardizing to the volume of the immunoprecipitated TDP-43-GFP signal at ~ 70 kDa, and normalizing to the stressed positive control sample without sgRNA on each blot

first, APOE 4 positive cells are more readily infected, and those cells create more inflammation as compared to APOE 4 negative cells, due to the proteins ability to downregulate the ACE2 enzyme