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Huntington's disease Huntington's disease (HD) is a chronic neurodegenerative disease and a hereditary autosomal-dominant disorder of the central nervous system caused by a single genetic mutation (Ross et al., ), characterized by neuronal death in caudate and putamen and in the cerebral cortex, and to a lesser extent in hippocampus and subthalamic nucleus (Mehrotra et al., )

Figure 3 Figure 4 Recently the Brimble group have applied divinyl diester staples to thiol-ene peptide stapling of Cys-containing peptides, providing access to a significantly more hydrophilic staple than traditional hydrocarbon staples (Figure 3C)

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