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The dysregulation of vesicle secretion and composition represents a fundamental mechanism linking obesity to systemic metabolic dysfunction

p53 p53 is one of the most well-studied tumor suppressor, and is activated in response to various stressors including DNA damage, telomere attrition, mitochondrial, oxidative or oncogenic stress

112 Guerreiro G, Amaral AU, Ribeiro RT, Faverzani J, Groehs AC, Sitta A, Deon M, Wajner M, Vargas CR (2019) l-Carnitine prevents oxidative stress in striatum of glutaryl-CoA dehydrogenase deficient mice submitted to lysine overload

However, so far, no significant adverse effects have been consistently reported