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By pairwise combination screening, the combination of curcumin (Cur) at 15 M and luteolin (LUT) at 30 M (C15L30) synergistically suppressed the proliferation of human colon cancer CL-188 cells, but the individual chemicals had a little inhibitory effect at the selected concentrations

Current clinical research on microbiota-targeted therapies for ALD highlights promising advancements, including probiotic supplementation (e.g., Lactobacillus rhamnosus GG in a Phase 2 trial, NCT05178069), encapsulated FMT progressing to Phase 3 evaluation (NCT06461208), and active investigation of bacteriophage therapies and symbiotic blends to mitigate gut dysbiosis

doi: 10.1016/j.bbmt.2018.12.758

Anti-Inflammation: Reducing oxidative stress and suppressing pro-inflammatory molecules like TNF-alpha and IL-6