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Curcumin as a steroid-sparing agent is another area of research, such as the use of lower doses of steroids in OLP or OSF when curcumin is concurrently administered, to evaluate whether this reduces steroid side effects while maintaining efficacy

Further, the concentration of free metal ions in in vivo is thought to be very low as iron and other metals are sequestered by various metal binding proteins [94]

In the FVB/N-TgN(v-Ha- ras )Led (Tg.AC) hemizygous male and female mice, histopathology did not show cell proliferation or hyperplasia in any of the tissues evaluated