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Description

In anti-GAD65Ab-associated CAs, anti-GAD65Ab impairs the association of GAD65 with the cytosolic side of SVs resulting in a decrease in vesicular GABA contents with low release probability [82]

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Collectively, these mechanisms contribute to an elevated risk of depression and other ADRs ( HIV activates the NLRP3 inflammasome in microglial cells upon infection, leading to the activation of both microglial cells and astrocytes, which fosters chronic inflammation in the brain and heightens the risk of depression