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People who do not eat meat or dairy products, women who are pregnant or breastfeeding, and people with certain genetic conditions may have a hard time getting vitamin B from their diets

Other indirect evidence also comes from the coordinated response of enzyme activities and corresponding gene expression that is often observed in response to stress

This mechanism increases intracellular concentrations of both NAD+ and SAM, two fundamental molecules that regulate cellular energy expenditure, mitochondrial function, and epigenetic modifications

By synthesizing the existing literature, we delve into the potential value of PPE in biomedicine, the challenges currently encountered, and the future directions for research