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While current strategies focuses on mitigationusing antioxidants, NAD+ precursors, and metabolic modulators to support mitochondrial functionthe future lies in targeted, potentially curative interventions

It also contributes to muscle bulking and fat drop over time

The HIFEPO axis serves as a crucial connection between environmental oxygen levels and red blood cell molecular homeostasis, with important consequences for physiological adaptation and disease development (55)

Briefly, the coding sequence (CDS) of HrGSTm1 was cloned into the pET-32a(+) vector (TaKaRa, Shiga, Japan) with Bam HI and Hin dIII restriction sites, then transformed into competent Escherichia coli (DE3) cells (AxyGen, Shanghai, China) and cultured at 37 C for 24 h