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Indeed, the phosphorylation of JNK and its downstream substrates c-Jun and activating transcription factor 2 (ATF2) were higher in the livers of Gstp1/2 / mice than in the WT livers

Over time, results plateau if therapy isnt cycled properly

Mitochondria regulate lipid metabolism, mitochondrial dysfunction can lead to disruption of lipid homeostasis and oxidative stress, which are major contributors to NASH ( ( Figure 3 )