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In addition, DIM may activate Nrf2, a key cellular signaling pathway that regulates antioxidant activity and detoxification

Jiyah A, Muhammad SA, Ibrahim A, Bulama I, Ibrahim A, Abbas AY, et al

Aug 2013;23(3):273-285

Stromal interaction molecule 1 (STIM1) detects ER calcium depletion, translocates to ER-plasma membrane junctions, and activates Ca 2+ release-activated channels (CRAC) by tethering Orai proteins, triggering CaMKK activation, which phosphorylates AMPK at Thr172