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Platelet-secreted chemokine platelet factor 4 (PF4/CXCL4) improves age-related cognitive impairment through hippocampal neurogenesis, which is the key to delaying the aging of the brain

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As a result, we are unclear about the strength of direct association between VEST and clinical outcome improvement, or whether any outcomes are inferred from surrogate endpoints

The availability of software applications to conveniently implement FBA and related in silico methods 20 has enabled the development of genome-scale models (GEMs) for more than 100 species across all three domains of life, thereby facilitating analysis of their intracellular metabolism 21