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Furthermore, aside of its transcriptional regulation, the zinc-regulated surface accumulation of ZnT-1 might also be facilitated on a post-transcriptional level, whereas, during zinc deficiency, the protein is degraded via lysosomal and proteasomal pathways [138]

The transformation was made by lithium acetate and PEG method according to MatchMaker protocol (Clontech)

Despite its methodological limitations, this study provides a foundation for future controlled studies aimed at refining topical antioxidant-based therapies and advancing personalized approaches for this multifactorial pain disorder