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The molecule was first identified and studied by the Sikiric research group in Croatia starting in the early 1990s, and the bulk of the preclinical evidence base comes from more than three decades of rat and rodent studies showing consistent tissue-repair, anti-inflammatory, and gastroprotective effects

Materials and Methods The authors used the Broad Institute's Connectivity Map (CMap) - a publicly available computer-based gene profiling tool

This notion is illustrated by MASLD and MASH pathobiology [99] pointing to the investigation of coppers role as a potential avenue to uncover important sex-specific pathogenic mechanisms of MASLD initiation, and fibrotic progression [49,58,79,100-102] and the development of targeted therapies that, moving beyond symptomatic treatment, address the underlying root causes of MASLD in individual patients [86]

Reduces inflammation a major driver of skin aging, redness, and sensitivity