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Abstract Anxiety disorders are major neuropsychiatric conditions linked to oxidative stress, neuroinflammation, and dysregulated neurotransmission

Notably, several methylene thioacetal modified lead compounds have advanced into clinical evaluation, underscoring the high translational potential of this strategy

Oncogene 32 , 37653781 (2013)

[168] recently demonstrated for the first time the ability of polymetformin to block the AGERAGE signaling pathway and attenuate AGE-mediated cardiovascular complications