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Within the triple quadrupole configuration, the first quadrupole isolates analyte molecules, the second quadrupole fragments select molecular ions, and the third quadrupole selectively isolates the ions for measurement via a detector

In a previous study, mitochondrial fusion protein-2 (MFN2) enhanced mitochondria-endoplasmic reticulum (ER) contact and fostered inflow of mitochondrial Ca 2+ required for efficient mitochondrial metabolism by interacting with the ER-embedded Ca-ATPase SERCA2, thereby preventing mitochondrial Ca 2+ overaccumulation and apoptosis

doi: 10.3389/fphar.2021.770663