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20,33,106 Individuals with early-onset and progressive liver disease, unexplained cholestasis, ICP, LPAC, drug-induced cholestasis, or a family history of cholestatic diseases should consider genetic testing for ABC transporter mutations

While it may be possible to generate microglia-containing COs, these spontaneous formation, self-directed protocols are not yet robust and well established in terms of cell ratio and heterogeneity between patient iPSC lines

the Linde Family Foundation and the Novartis Biomedical Research DDTRP program for supporting S.D.-P., I.M.G