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10.1016/S0140-6736(20)30925-9 33 DogaruC

Transcription factor Nrf2 is activated in response to ROS-induced oxidative stress and triggers the expression of its target genes through binding to antioxidant response elements (Ma 2013)

Three times a day dosing Effect half half of 9.4 hrs Compared to reserpine, tetrabenazine has a more rapid onset of action, and more rapid reduction of side effects with dose reduction, making it easier to dose

[1] [3] The active ingredient, ascorbic acid, is a water-soluble vitamin essential for numerous physiological functions, including collagen synthesis, antioxidant defense, and immune support